Symbol
Name
ID

Card11
caspase recruitment domain family, member 11
MGI:1916978

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Reduced antigen-specific T cell proliferation	Increased circulating IgE level	Decreased circulating total IgM	Decreased circulating antibody level	Agammaglobulinemia	Eosinophilia	Decreased proportion of CD4+CD25+ regulatory T cells	Monocytopenia
Disease(s) Associated with CARD11	Reduced antigen-specific T cell proliferation	Increased circulating IgE level	Decreased circulating total IgM	Decreased circulating antibody level	Agammaglobulinemia	Eosinophilia	Decreased proportion of CD4+CD25+ regulatory T cells	Monocytopenia
immunodeficiency 11A
immunodeficiency 11B

Mouse Phenotypes

abnormal B cell proliferation

decreased B cell proliferation

increased B cell proliferation

abnormal T cell proliferation

decreased T cell proliferation

abnormal thymus morphology

enlarged thymus

enlarged spleen

spleen hyperplasia

abnormal B cell differentiation

absent immature B cells

decreased transitional stage T1 B cell number

decreased transitional stage T3 B cell number

increased transitional stage T2 B cell number

abnormal plasma cell differentiation

abnormal T cell differentiation

abnormal T-helper 2 cell differentiation

abnormal double-negative T cell morphology

decreased germinal center B cell number

increased germinal center B cell number

decreased mature B cell number

decreased B-1 B cell number

absent B-1a cells

decreased B-1a cell number

decreased marginal zone B cell number

increased B-1 B cell number

increased B-1a cell number

increased B-1b cell number

increased follicular B cell number

increased marginal zone B cell number

decreased B cell number

decreased pre-B cell number

increased pre-B cell number

decreased NK cell number

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

decreased central memory CD4-positive, alpha-beta T cell number

decreased effector memory CD4-positive, alpha-beta T cell number

increased CD4-positive, alpha-beta T cell number

decreased effector memory CD8-positive, alpha-beta T cell number

increased CD8-positive, naive alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased NK T cell number

increased NK T cell number

increased alpha-beta T cell number

decreased effector memory T-helper cell number

increased T-helper cell number

decreased gamma-delta T cell number

decreased memory T cell number

decreased regulatory T cell number

increased T cell number

increased lymphocyte cell number

increased leukocyte cell number

abnormal lymphocyte morphology

abnormal germinal center B cell morphology

abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology

abnormal spleen morphology

decreased spleen weight

small spleen

abnormal B cell physiology

decreased IgA level

decreased IgE level

increased IgE level

decreased IgG1 level

decreased IgG2a level

decreased IgG2b level

decreased IgG2c level

decreased IgG3 level

decreased IgG level

decreased IgM level

decreased immunoglobulin level

increased immunoglobulin level

abnormal NK cell physiology

abnormal cytotoxic T cell physiology

abnormal T cell activation

Availability

Mouse Genotype

Card11^{em1(IMPC)Ccpcz}/Card11^{em1(IMPC)Ccpcz}

Card11^em1Welu/Card11^em1Welu

Card11^em2Welu/Card11^em2Welu

Card11^em3Welu/Card11^em3Welu

Card11^m1Btlr/Card11^m1Btlr

Card11^M2Btlr/Card11^M2Btlr

Card11^m3Btlr/Card11^m3Btlr

Card11^M4Btlr/Card11^M4Btlr

Card11^M5Btlr/Card11^M5Btlr

Card11^M6Btlr/Card11^M6Btlr

Card11^M7Btlr/Card11^M7Btlr

Card11^m8Btlr/Card11^m8Btlr

Card11^tm1Litt/Card11^tm1Litt

Card11^tm1Pngr/Card11^tm1Pngr

Card11^tm1Vmd/Card11^tm1Vmd

Card11^tm1Xav/Card11^tm1Xav

Card11^unm/Card11^unm

Card11^em1Welu/Card11⁺

Card11^em2Welu/Card11⁺

Card11^M4Btlr/Card11⁺

Card11^M5Btlr/Card11⁺

Card11^tm1Vmd/Card11⁺

Card11^tm1.1Litt/Card11^tm1.1Litt
Tnfrsf4^tm2(cre)Nik/Tnfrsf4⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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